Synthesis of Complex Glycolates by Enantioconvergent Addition Reactions
نویسندگان
چکیده
منابع مشابه
Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation
A dynamic kinetic resolution of β-halo α-keto esters in an asymmetric homoenolate reaction is described. A chiral N-hetereocyclic carbene catalyzes the a(3) → d(3)-umpolung addition of α,β-enals to racemic α-keto esters, forming γ-butyrolactones with three contiguous stereocenters. The addition occurs with high regio-, diastereo-, and enantiocontrol. This methodology constitutes an intermolecul...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2017
ISSN: 0001-4842,1520-4898
DOI: 10.1021/acs.accounts.7b00263